专利名称：Lentiviral vectors for the preparation of
immunotherapeutical compositions
发明人：Pierre Charneau,Huseyin Firat,Véronique
Zennou
申请号：US13711898申请日：20121212公开号：US08652807B2公开日：20140218
摘要：The invention relates to an immunogenic composition comprising a recombinantvector characterized in that it comprises a polynucleotide comprising the cis-actingcentral initiation region (cPPT) and the cis-acting termination region (CTS), these regionsbeing of retroviral or retroviral-like origin, said vector comprising in addition a definednucleotide sequence (transgene or sequence of interest) and regulatory signals ofretrotranscription, expression and encapsidation of retroviral or retroviral-like origin,wherein the composition is capable of inducing or of stimulating a cell-mediatedresponse for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response,against one or several epitopes encoded by the transgene sequence present in thevector.
申请人：Institut Pasteur,Institut National de la Santé et de la RechercheMédicale,Centre National de la Recherche Scientifique
地址：Paris FR,Paris FR,Paris FR
国籍：FR,FR,FR
代理机构：Law Office of Salvatore Arrigo and Scott Lee, LLP
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