专利名称:METHOD FOR THE PREPARATION OF
CITALOPRAM
发明人:COTTICELLI, Giovanni,DI LERNIA,
Gianluca,MILANESI, Silvia
申请号:EP04791287.8申请日:20041022公开号:EP1682526B1公开日:20090114
摘要:A method for the preparation of citalopram and its pharmaceutically acceptablesalts is described; it's obtained starting from 5-cyanophthalide by reaction with a mixtureof 4fluorophenyl magnesium bromide and 3-dimethylaminopropyl magnesium chloride.The intermediate obtained is showed here-below: wherein X is an halogen, preferablychlorine or bromine, which is cyclized without any isolation.
申请人:ADORKEM TECHNOLOGY SPA
地址:IT
国籍:IT
代理机构:Pistolesi, Roberto
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