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METHOD FOR THE PREPARATION OF CITALOPRAM

来源:个人技术集锦
专利内容由知识产权出版社提供

专利名称:METHOD FOR THE PREPARATION OF

CITALOPRAM

发明人:COTTICELLI, Giovanni,DI LERNIA,

Gianluca,MILANESI, Silvia

申请号:EP04791287.8申请日:20041022公开号:EP1682526B1公开日:20090114

摘要:A method for the preparation of citalopram and its pharmaceutically acceptablesalts is described; it's obtained starting from 5-cyanophthalide by reaction with a mixtureof 4fluorophenyl magnesium bromide and 3-dimethylaminopropyl magnesium chloride.The intermediate obtained is showed here-below: wherein X is an halogen, preferablychlorine or bromine, which is cyclized without any isolation.

申请人:ADORKEM TECHNOLOGY SPA

地址:IT

国籍:IT

代理机构:Pistolesi, Roberto

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