专利名称：DISUBSTITUTED
PYRAZOLOBENZODIAZEPINES USEFUL ASINHIBITORS FOR CDK2 AND ANGIOGESIS,AND FOR THE TREATMENT OF BREAST,COLON, LUNG AND PROSTATE CANCER
发明人：LIU, Jin-Jun,LUK, Kin-Chun,PIZZOLATO,
Giacomo,REN, Yi,THAKKAR, KshitijChhabilbhai,WOVKULICH, Peter,Michael,ZHANG, Zhuming
申请号：EP05792946.5申请日：20051004公开号：EP1802625B1公开日：20080618
摘要：The present invention provides compounds of the formula (I) wherein R1, R2, R3and R4 are described herein. The invention also provides syntheses for preparation ofsuch compounds and pharmaceutical compositions containing them. The invention furtherprovides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis,and for treating cancers, in particular breast, colon, prostate, and lung cancer.
申请人：HOFFMANN LA ROCHE
地址：CH
国籍：CH
代理机构：Klein, Thomas
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