专利名称：REGULATION OF TRANSCRIPTION IN
MAMMALIAN CELLS AND VIRALREPLICATION BY A TETRACYCLINREPRESSOR
发明人：YAO, Feng申请号：EP98924964.4申请日：19980529公开号：EP0990041B1公开日：20060628
摘要：The present invention is directed to DNA constructs suitable for geneexpression in mammalian cells and which are characterized by the presence of amammalian promoter under the control of a tet operator/repressor system. The DNAmay be used as part of a system for expressing recombinant protein. In addition, the tetoperator/repressor system can be used to engineer cis- and trans-destructive viruseswhich are capable of replicating in the presence of the tet repressor, but not in theabsence of the repressor. These viruses can be used either directly in the treatment ofpatients with corresponding viral diseases, as vehicles for the delivery of nucleic acids thatcan serve as therapeutic agents and as part of vaccines designed to immunize people oranimals against viral diseases.
申请人：BRIGHAM & WOMENS HOSPITAL
地址：US
国籍：US
代理机构：Perry, Robert Edward
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