MICROFLUIDIC DEVICE FOR CELL SEPARATION AND USES T

专利名称：MICROFLUIDIC DEVICE FOR CELL

SEPARATION AND USES THEREOF

发明人：TONER, Mehmet,TRUSKEY, George,KAPUR,

Ravi

申请号：EP03798803.7申请日：20030929公开号：EP1569510A2公开日：20050907

摘要：The invention features methods for separating cells from a sample (e.g.,separating fetal red blood cells from maternal blood). The method begins with theintroduction of a sample including cells into one or more microfluidic channels. In oneembodiment, the device includes at least two processing steps. For example, a mixture ofcells is introduced into a microfluidic channel that selectively allows the passage of adesired type of cell, and the population of cells enriched in the desired type is thenintroduced into a second microfluidic channel that allows the passage of the desired cellto produce a population of cells further enriched in the desired type. The selection ofcells is based on a property of the cells in the mixture, for example, size, shape,deformability, surface characteristics (e.g., cell surface receptors or antigens andmembrane permeability), or intracellular properties (e.g., expression of a particularenzyme).

申请人：THE GENERAL HOSPITAL CORPORATION,GPB Scientific LLC

地址：55 Fruit Street Boston, MA 02114 US,One Kendall Square Cambridge, MA 02139US

国籍：US,US

代理机构：Adam, Holger

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