专利名称：ISOLATION AND CHARACTERIZATION OF
THE PRECURSOR VIRUS OF HUMAN SARSVIRUS: SARS-ASSOCIATED CORONA VIRUS-LIKE VIRUS
发明人：Yi Guan,Bo-Jiang Zheng申请号：US10852357申请日：20040524
公开号：US20080069839A1公开日：20080320
摘要：The present invention relates to isolation and characterization of a class ofisolated novel viruses which is the precursor of the virus causing Severe Acute RespiratorySyndrome (SARS) in humans (“hSARS virus”). The precursor virus which is a SARScoronavirus-like virus (“SCoV-like virus”) is identified to be morphologically andphylogenetically similar to hSARS virus. The present invention relates to a nucleotidesequence comprising the genomic sequence of the SCoV-like virus. The invention furtherrelates to nucleotide sequences comprising a portion of the genomic sequence of theSCoV-like virus. The invention also relates to the deduced amino acid sequences of theSCoV-like virus. The invention further relates to the nucleic acids and peptides encodedby and/or derived from these sequences and their use in diagnostic methods and
therapeutic methods. The invention further encompasses chimeric or recombinant virusesencoded by said nucleotide sequences and antibodies directed against polypeptidesencoded by the nucleotide sequences. Furthermore, the invention relates to vaccinepreparations comprising the SCoV-like virus, including recombinant and chimeric forms of
said virus.
申请人：Yi Guan,Bo-Jiang Zheng
地址：Hong Kong CN,Hong Kong CN
国籍：CN,CN
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