专利名称：ALTERED N-CADHERIN PROCESSING IN
TUMOR CELLS BY FURIN AND PROPROTEINCONVERTASE 5A (PC5A)
发明人：MARET, DEBORAH,COLMAN, DAVID,
R.,GRUZGLIN, EUGENIA,SEIDAH, NABIL
申请号：EP08843796申请日：20081103公开号：EP2211897A4公开日：20110413
摘要：The present invention relates to a method for diagnosis and/or prognosis ofcancer and for monitoring the progression of cancer and/or the therapeutic efficacy of ananti-cancer treatment in a subject by determining the molecular form of cadherin at thecell surface of cancer cells in the subject. The invention also relates to a method forpreventing, inhibiting or treating cancer or its metastasis in a subject by increasing theadhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at thecell surface. The invention also relates to a method step of determining the expressionlevel of furin and proprotein convertase 5A (PC5A).
申请人：THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILLUNIVERSITY,IRCM (INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL),MOUNT SINAISCHOOL OF MEDICINE
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