Methods relating to immunogenic dextran-protein co

专利名称：Methods relating to immunogenic dextran-protein conjugates

发明人：Denong Wang,Bernard F. Erlanger,Elvin A.

Kabat

申请号：US09149997申请日：19980909公开号：US06287568B1公开日：20010911

摘要：This invention includes the conception of T-independent conjugate-vaccines andits application in the induction of antigen specific IgA response. We demonstrated that 1)&agr;(1,6)dextran can elicit a markedly enhanced IgA response in T-cell free mice (20-50fold higher than in normal mice); 2)co-injection of the molecule with other antigens canenhance the IgA response to the co-antigen; and 3)a dextran-Gag conjugate can elicit theGag-specific IgA. Thus, the invention identified &agr;(1,6)dextran as a carrier molecule forproducing the T-independent conjugates and as an adjuvant for the enhancement of IgAproduction. The T-independent property of these conjugates makes it especially useful invaccinations against HIV and other infectious and non-infectious diseases associated withT-cell deficiency.

申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

代理机构：Cooper & Dunham LLP

代理人：John P. White

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