专利名称：Benzoic acid, benzoic acid derivatives and
heteroaryl carboxylic acid conjugates ofhydrocodone, prodrugs, methods of makingand use thereof
发明人：Travis Mickle,Sven Guenther,Christal
Mickle,Guochen Chi,Jaroslaw Kanski,AndreaK. Martin,Bindu Bera
申请号：US12828381申请日：20100701公开号：US08461137B2公开日：20130611
摘要：The presently described technology provides compositions comprising arylcarboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone,including benzoates and heteroaryl carboxylic acids, which have a decreased potential forabuse of hydrocodone. The present technology also provides methods of treatingpatients, pharmaceutical kits and methods of synthesizing conjugates of the presenttechnology.
申请人：Travis Mickle,Sven Guenther,Christal Mickle,Guochen Chi,JaroslawKanski,Andrea K. Martin,Bindu Bera
地址：Coralville IA US,Coralville IA US,Coralville IA US,North Liberty IA US,BlacksburgVA US,Fincastle VA US,Blacksburg VA US
国籍：US,US,US,US,US,US,US
代理机构：McAndrews, Held & Malloy, Ltd.
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